Objective: To investigate the relationship between serum level of cystatin C\n(Cys-C) and AF (atrial fibrillation) and its clinical classification. Method:\nFrom January 2017 to April 2019, 168 cases of Xiaogan Central Hospital were\nchosen as the object of this study. The subjects were divided into 86 patients\nwith AF and 82 patients in the control group. The AF group was divided into\nparoxysmal AF group (29 cases), persistent AF group (27 cases) and permanent\nAF group (29 cases) according to the European atrial fibrillation management\nguidelines and the North America Society of Pacing and Electrophysiology\n(NASPE) arrhythmia group organized the categorization of AF. Results:\nCompared with the control group, the level of the serum Cys-C was\nsignificantly higher in the AF group, the difference was statistically significant\n(P < 0.05). There was significant difference in Cys-C level in patients\nwith different types of AF (P < 0.05). The levels of neutrophil percentage, low\ndensity lipoprotein cholesterol (LDL-C), left ventricular diameter, left atrial\ndiameter, C-reactive protein (CRP) and homocysteine in the AF group were\nsignificantly higher than those in the control group (P < 0.05). The difference\nof neutrophil percentage, LDL-C, left ventricular ejection fraction, left atrial\ndiameter, CRP and homocysteine levels in patients with different types of\natrial fibrillation was statistically significant (P < 0.05). Logistic analysis showed\nthat the serum Cys-C level, CRP, homocysteine, left ventricular diameter, left\natrial diameter could be used as an independent predictor of atrial fibrillation\nwhen other factors were corrected. Conclusion: Serum Cys-C level in atrial\nfibrillation group is significantly higher than the control group, there are differences\nbetween different atrial fibrillation clinical classification, its level increased\nwith duration of atrial fibrillation. Serum Cys-C level and inflammatory\nmarkers CRP, WBC and neutrophilic granulocyte percentage were positively\ncorrelated, indicating that serum cystatin C is associated with chronic\ninflammation, involved in the occurrence of atrial fibrillation, maintain and\nrecurrence. Logistic analysis showed that the serum cystatin C level could be\nused as an independent predictor of atrial fibrillation when other factors were\ncorrected.
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